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Perfiles Destacados

Luis Concha, PhD
Luis Concha, PhD
Senior Scientist
Amprion, San Diego
“Mi rol en este lugar es desarrollar nuevos métodos analíticos de detección de priones, igual de sensibles y específicos como la PMCA y así identificarlos de manera certera al momento de diagnosticar enfermedades causadas por este agente infeccioso"
Ignacio Fernández Chicharro, MS, PhD(c)
Ignacio Fernández Chicharro, MS, PhD(c)
Estudiante de Doctorado
Arizona State University
"El trabajo que realizo junto a mis colaboradores tiene directa implicancia para la toma de decisiones en nuestro país"

Artículos Científicos


LI, ZENGGANG; IVANOV, ANDREI; SU, RINA; GONZALEZ-PECCHI, VALENTINA; QI, QI; LIU, SONGLIN; WEBBER, PHILIP; MCMILLAN, ELIZABETH; RUSNAK, LAUREN; PHAM, CAU; CHEN, XIAOQIAN; MO, XIULEI; REVENNAUGH, BRIAN; ZHOU, WEI; MARCUS, ADAM; HARATI, SAHAR; CHEN, XIANG; JOHNS, MARGARET; WHITE, MICHAEL; MORENO, CARLOS; COOPER, LEE; DU, YUHONG; KHURI, FADLO & FU, HAIAN. The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies. Nat. Communic., 8:14356, 2017. http://www.nature.com/articles/ncomms14356

RAMÍREZ, MARÍA PAZ; RIVERA, MAIRA; QUIROGA-ROGER, DIEGO; BUSTAMANTE, ANDRÉS; VEGA, MARCELA; BAEZ, MAURICIO; PUCHNER, ELIAS & WILSON, CHRISTIAN. Single molecule force spectroscopy reveals the effect of BiP chaperone on protein folding. Protein Sci.,  2017. doi:10.1002/pro.3137. http://onlinelibrary.wiley.com/doi/10.1002/pro.3137/abstract

SEPÚLVEDA, HUGO; AGUILAR, RODRIGO; PRIETO, CATALINA; BUSTOS, FRANCISCO; AEDO, SÓCRATES; LATTUS, JOSÉ; VAN ZUNDERT, BRIGITTE; PALMA, VERÓNICA & MONTECINO, MARTÍN. Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells. J. Cell. Physiol., 2017. http://onlinelibrary.wiley.com/doi/10.1002/jcp.25627/abstract;jsessionid=C8F60BE75B46B1CB04E9982ECFC173D2.f04t02

VÁSQUEZ, BÉLGICA; OLATE, SERGIO; CANTÍN, MARIO; SANDOVAL, CRISTIAN; DEL SOL, MARIANO & DE MORAES, MARCIO. Histomorphometric analysis of unilateral condylar hyperplasia in TMJ. The value of condylar layer and cartilage island. Int. J. Oral Maxillofac. Surg., IN PRESS, 2017.


AGUILAR, RODRIGO; BUSTOS, FERNANDO; SÁEZ, MAURICIO; ROJAS, ADRIANA; ALLENDE, MIGUEL; VAN WIJNEN, ANDRE; VAN ZUNDERT, BRIGITTE & MONTECINO, MARTÍN. Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus. Biochim. Biophys. Acta, 1859(8):1043-55, 2016. http://www.sciencedirect.com/science/article/pii/S1874939916300992

ALARCON, VALENTINA; HERNÁNDEZ, SERGIO; RUBIO, LORENA; ALVAREZ, FRANCISCA; FLORES, YVO; VARAS-GODOY, MANUEL; DE FERRARI, GIANCARLO; KANN, MICHAEL; VILLANUEVA, RODRIGO &  LOYOLA, ALEJANDRA. The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state. Sci. Rep., 6:25901, 2016. http://www.nature.com/articles/srep25901

CONCHA-MARAMBIO, LUIS; PRITZKOW, SANDRA; MODA, FABIO; TAGLIAVINI, FABRIZIO; IRONSIDE, JAMES; SCHULZ, PAUL & SOTO, CLAUDIO. Detection of prions in blood from patients with variant Creutzfeldt-Jakob disease. Sci. Transl. Med., 8(370):370ra183, 2016. http://stm.sciencemag.org/content/8/370/370ra183.short

EL NAJJAR, FARAH; CIFUENTES-MUÑOZ, NICOLÁS; CHEN, JING; ZHU, HAINING; BUCHHOLZ, URSULA; MONCMAN, CAROLE & DUTCH, REBECCA. Human metapneumovirus induces reorganization of the actin cytoskeleton for direct cell-to-cell spread. PLoS Pathog.,12(9):e1005922, 2016. 

FERNÁNDEZ, IGNACIO; MANUEL-NAVARRETE, DAVID & SALINAS-TORRES, ROBINSON. Breaking Resilient Patterns of Inequality in Santiago de Chile: Challenges to Navigate towards a More Sustainable City. Sustainability, 8(8):820, 2016. http://www.mdpi.com/2071-1050/8/8/820

FERNÁNDEZ, IGNACIO & WU, JIANGUO. Assessing environmental inequalities in the city of Santiago (Chile) with a hierarchical multiscale approach. Appl. Geogr., 74:160-9, 2016. http://www.sciencedirect.com/science/article/pii/S0143622816302545

FERNÁNDEZ, IGNACIO & MORALES, NARKIS. A spatial multi-criteria decision analysis for selecting priority sites for plant species restoration: A case study from the Chilean biodiversity hotspot. Restor. Ecol., 24(5):599-608, 2016. http://onlinelibrary.wiley.com/doi/10.1111/rec.12354/abstract

HERNÁNDEZ, SERGIO; JIMÉNEZ, GUSTAVO; ALARCÓN, VALENTINA; PRIETO, CRISTIAN; MUÑOZ, FRANCISCA; RIQUELME, CONSTANZA; VENEGAS, MAURICIO; BRAHM, JAVIER; LOYOLA, ALEJANDRA & VILLANUEVA; RODRIGO. Replication of a chronic hepatitis B virus genotype F1b construct. 2016. Arch. Virol., 161(3):583-94, 2016. https://link.springer.com/article/10.1007%2Fs00705-015-2702-x

LOPEZ, CECILIA; SAUD, KATHERINE; AGUILAR, RODRIGO; BERNDT, ANDRÉS; CANOVAS, JOSÉ; MONTECINO, MARTÍN & KUKULJAN, MANUEL. The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development. Develop. Neurobiol., 76(12):1360-73, 2016. http://onlinelibrary.wiley.com/doi/10.1002/dneu.22397/abstract

SANDOVAL, CRISTIAN & VÁSQUEZ, BÉLGICA. Evaluación de reactividad inmunohistoquímica con método del complejo avidina – biotina (ABC). Int. J. Med. Surg. Sci., 3(3):909-18, 2016. http://www.ijmss.org/wp-content/uploads/2016/10/art_03_33.pdf

SCHENCKE, CAROLINA; VÁSQUEZ, BÉLGICA; SANDOVAL, CRISTIAN & DEL SOL, MARIANO. The role of honey in the morphophysiologic processes of wound repair. Int. J. Morphol., 34(1):385-95, 2016. http://www.intjmorphol.com/wp-content/uploads/2016/04/art_56_341.pdf

SCHENCKE, CAROLINA; VASCONCELLOS, ADRIANA; SANDOVAL, CRISTIAN; TORRES, PAULINA; ACEVEDO, FRANCISCA & DEL SOL, MARIANO. Morphometric evaluation of wound healing in burns treated with Ulmo (Eucryphia cordifolia) honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus). Burns & Trauma, 4(25):1-9, 2016. https://burnstrauma.biomedcentral.com/articles/10.1186/s41038-016-0050-z

VÁSQUEZ, BÉLGICA; SANDOVAL, CRISTIAN; SMITH, RICARDO LUIZ & DEL SOL, MARIANO. Effects of early and late adverse experiences on intake behavior of rats subjected to stress during adulthood. Interciencia, 41(3):177-83, 2016. http://www.interciencia.org/v41_03/177.pdf

VÁSQUEZ, BÉLGICA; OLATE, SERGIO; CANTÍN, MARIO; SANDOVAL, CRISTIAN; FARIÑA, RODRIGO & DEL SOL, MARIANO. Histopathological analysis of unilateral condylar hyperplasia: difficulties in diagnosis and characterization of the disease. Int. J. Oral Maxillofac. Surg., 45(5):601-9, 2016. http://dx.doi.org/10.1016/j.ijom.2015.11.023

VÁSQUEZ-DOORMAN, CONSTANZA & PETERSEN, CHRISTIAN P. The NuRD complex component p66 suppresses photoreceptor neuron differentiation in planarian head regeneration. Regeneration, 18;3(3):168-78, 2016. http://onlinelibrary.wiley.com/doi/10.1002/reg2.58/full


CÁNOVAS, JOSÉ; BERNDT, ANDRÉS; SEPÚLVEDA, HUGO; AGUILAR, RODRIGO; VELOSO, FELIPE; MONTECINO, MARTÍN; OLIVA, CARLOS; MAASS, JUAN; SIERRALTA, JIMENA & KUKULJAN, MANUEL. The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a. J. Neurosci., 35(19): 7552-64, 2015. http://www.jneurosci.org/content/jneuro/35/19/7552.full.pdf

JARA, ROCÍO; SEPÚLVEDA, CAROLINA; IP, HON & SAMUEL, MICHAEL. Total protein concentration and diagnostic test results for gray wolf (Canis lupus) serum using Nobuto filter paper strips. J Wildl Dis., 51(2):475-8, 2015. http://www.bioone.org/doi/pdf/10.7589/2013-07-185

MONTECINO, MARTÍN; STEIN, GARY; STEIN, JANET; ZAIDI, KALEEM & AGUILAR, RODRIGO. Multiple Levels of Epigenetic Control for Bone Biology and Pathology. Bone. 81:733-8, 2015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600412/pdf/nihms680144.pdf

ROJAS, ADRIANA; AGUILAR, RODRIGO; HENRIQUEZ, BERTA; LIAN, JANE; STEIN, JANET; STEIN, GARY; VAN WIJNEN, ANDRE; VAN ZUNDERT, BRIGITTE; ALLENDE, MIGUEL & MONTECINO, MARTÍN. Epigenetic Control of the Bone-master Runx2 Gene During Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B. J. Biol. Chem., 290(47):28329-42, 2015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653688/pdf/zbc28329.pdf

VÁSQUEZ, BÉLGICA; SANDOVAL, CRISTIAN; SMITH, RICARDO LUIZ. & DEL SOL, MARIANO. Effects of early and late adverse experiences on morpho-quantitative characteristics of Spragüe-Dawley rat spleen subjected to stress during adulthood. Int. J. Clin. Exp. Pathol., 8(4): 3624-35, 2015. http://www.ijcep.com/files/ijcep0006208.pdf

VÁSQUEZ-DOORMAN, CONSTANZA; ROJAS, LUIS; BORIC, KATICA & MARTÍNEZ,  PAMELA. Where and what are Chilean researching in the USA?. F1000Posters, 6:232, 2015. https://f1000research.com/posters/1097696


AGUILAR, RODRIGO; GRANDY, RODRIGO; MEZA, DANIEL; SEPÚLVEDA, HUGO; PIHAN, PHILIPPE; VAN WIJNEN, ANDRE; LIAN, JANE; STEIN, GARY; STEIN, JANET & MONTECINO, MARTIN. A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. J. Cell. Physiol., 229(10):1521-8, 2014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135720/pdf/nihms608415.pdf

BECERRA, FERNANDO & ESCALA, ANDRÉS. The Interstellar Medium and Star Formation in Local Galaxies: Variations of the Star Formation Law in Simulations. ApJ., 786:56-68, 2014. http://iopscience.iop.org/article/10.1088/0004-637X/786/1/56

BECERRA, FERNANDO; GREIF, THOMAS; SPRINGEL, VOLKER & HERNQUIST, LARS. Formation of massive protostars in atomic cooling haloes. MNRAS, 446(3): 2380-93, 2015. https://academic.oup.com/mnras/article-abstract/446/3/2380/2892843

HASTIE, JESSICA; WILLIAMS, KYLE; SEPÚLVEDA, CAROLINA; HOUTMAN, JON; FOREST, KATRINA & ELLERMEIER, CRAIG. Evidence of a Bacterial Receptor for Lysozyme: Binding of Lysozyme to the Anti-σ Factor RsiV Controls Activation of the ECF σ Factor σV. PLoS Genet., 10(10):e1004643, 2014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183432/

HEPP, MATIAS; ALARCON, VALENTINA; DUTTA, ARNOB; WORKMAN, JERRY & GUTIÉRREZ, JOSÉ. Nucleosome remodeling by the SWI/SNF complex is enhanced by yeast high mobility group box (HMGB) proteins. Biochim Biophys Acta., 1839(9):764-72, 2014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134981/pdf/nihms-613771.pdf

VÁSQUEZ, BÉLGICA; SANDOVAL, CRISTIAN; SMITH, RICARDO LUIZ & DEL SOL, MARIANO. Effects of early and late adverse experiences on morphological characteristics of Spragüe-Dawley rat liver subjected to stress during adulthood. Int. J. Clin. Exp. Pathol., 7(8):4627-35, 2014. http://ijcep.com/files/ijcep0000952.pdf 

VÁSQUEZ-DOORMAN, CONSTANZA & PETERSEN, CHRISTIAN. zic-1 expression in planarian neoblasts after injury controls anterior pole regeneration. PLoS Genetics, 10(7):e1004452, 2014. http://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004452&type=printable


ALY, KHALED; BEEBE, EMILY; CHAN, CHI; GOREN, MICHAEL; SEPÚLVEDA CAROLINA; MAKINO, SHIN-ICHI, FOX, BRIAN & FOREST KATRINA. Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the Pseudomonas aeruginosa prepilin peptidase PilD. Microbiologyopen, 2(1): 94–104, 2013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584216/

HENRIQUEZ, BERTA; BUSTOS, FERNANDO; AGUILAR, RODRIGO; BECERRA, ALVARO; SIMON, FELIPE; MONTECINO, MARTIN & VAN ZUNDERT, BRIGITTE. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Mol. Cell. Neurosci., 57:130-43, 2013. http://www.sciencedirect.com/science/article/pii/S104474311300078X

IBAR, CONSUELO; CATALDO, VICENTE; VÁSQUEZ-DOORMAN, CONSTANZA; OLGUÍN, PATRICIO & GLAVIC, ÁLVARO. Drosophila p53-related protein kinase is required for PI3K/TOR pathway-dependent growth. Development, 140(6):1282-91, 2013. http://dev.biologists.org/content/develop/140/6/1282.full.pdf

VÁSQUEZ, BÉLGICA; SANDOVAL, CRISTIAN; SANHUEZA, CARLA; SILVA, JAIME & DEL SOL, MARIANO. Effects of early and late adverse experiences in morphometric and stereological characteristics of the adrenal gland of Sprague Dawley rats subjected to stress during adulthood. J. Morphol., 31(1):15-22, 2013. http://www.scielo.cl/pdf/ijmorphol/v31n1/art02.pdf



AGUILAR, RODRIGO. Beca de Postdoctorado en el Extranjero BECAS CHILE. Convocatoria 2016. Beca otorgada por la Comisión Nacional de Investigación Científica y Tecnológica (CONICYT). Santiago, Chile.


SANDOVAL, CRISTIAN. Beca de Doctorado Nacional para estudios de Doctorado en Chile. Año Académico 2015. Beca otorgada por la Comisión Nacional de Investigación Científica y Tecnológica (CONICYT). Santiago, Chile. 


GONZALEZ, VALENTINA. Beca Fulbright-Chile para estudios de Doctorado en Estados Unidos. Año Académico 2013. Beca otorgada por la Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) y la Comisión para el Intercambio Educativo entre Chile y los Estados Unidos de América (FULBRIGHT). Santiago, Chile.  



CIFUENTES, NICOLÁS. Awarded as one of the selected talks for PostDoc Dean’s Distinguished Lecture Series. College of Medicine, University of Kentucky. Lexington, Kentucky. 2017.

PURCELL, PATRICIA. Trumpet Award of Chemistry and Chemical Biology Department, Harvard University. Harvard University. Boston, Massachusetts, Estados Unidos. 2017. The CCB Trumpet Award serves as a way for us to recognize those in our community who regularly excel in their positions and who go above and beyond in any of these areas: Teamwork, Responsibility, Utilization, Mentoring, Programing, Environment, Transformative (work or initiatives).

PURCELL, PATRICIA. Dean’s Distinction Award of Faculty of Arts and Sciences, Harvard University. Harvard University. Boston, Massachusetts, Estados Unidos. 2017. http://hr.fas.harvard.edu/deans-distinction


AGUILAR, RODRIGO. Premio Alumni por Investigación en Doctorado. Universidad Andrés Bello. Santiago, Chile. 2016.

AGUILAR, RODRIGO. Fellow Pew Latin American Fellows Program in the Biomedical Sciences. The Pew Charitable Trusts. Filadelfia, Estados Unidos. 2016.

MEDINA-FERRER, FERNANDO. Allan and Eleanor Martini Award, Department of Earth Sciences. University of Minnesota, Twin Cities. Newton Horace Winchell School of Earth Sciences, Department of Earth Sciences. University of Minnesota, Twin Cities. Minneapolis, Minnesota, USA. 2016.

RAMÍREZ, MARÍA PAZ. Medalla Osvaldo Cori, Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Santiago, Chile. 2016. http://www.quimica.uchile.cl/maria-paz-ramirez-ganadora-medalla-osvaldo-cori-2016/


SCHENCKE, CAROLINA; SANDOVAL, CRISTIAN; VÁSQUEZ, BÉLGICA & DEL SOL, MARIANO. Primer Puesto Categoría Póster, Modalidad Docente. XIV Congreso Nacional e Internacional de Ciencias Morfofisiológicas y I Congreso Paraguayo de Anatomía Humana. Presidente Franco, Paraguay. 11 al 12 de Septiembre, 2015. 

VÁSQUEZ-DOORMAN, CONSTANZA. Finalist. 2015 Northwestern University Presidential Fellowship. Northwestern University, Evanston, IL, Estados Unidos. 2015.


VÁSQUEZ-DOORMAN, CONSTANZA. IBiS Travel Award, TGS Travel Award and ISD Travel Award. 18th International Conference of the ISD in conjunction with the BSDB. Londres, Reino Unido. 02 al 05 de Noviembre, 2014.

VÁSQUEZ-DOORMAN, CONSTANZA. Nexos Chile-USA Best Poster Presentation Award. 5th Nexos Chile-USA Annual Meeting. Filadelfia, PA, Estados Unidos. 17 al 18 de Octubre, 2014.

VÁSQUEZ-DOORMAN, CONSTANZA. Constance Campbell Memorial Research Best Poster Presentation Award. 33rd Minisymposium on Reproductive Biology. Northwestern University, Evanston, IL, Estados Unidos. 16 de Abril, 2014.


BAEZA, ANGELO; DELAMA, MARÍA; SANDOVAL, CRISTIAN & DELAMA, I. Mejor Trabajo de Investigación, Categoría Medicina Interna. X Congreso Científico Temático de Estudiantes de Medicina. Santiago, Chile. 02 al 05 de Octubre, 2013. 

VÁSQUEZ-DOORMAN, CONSTANZA. Northwestern University Nominee. International Student Research Howard Hughes Medical Institute (HHMI) Fellowship. Northwestern University, Evanston, IL, Estados Unidos. 2013. 



VARGAS, CLAUDIA; SANDOVAL, CRISTIAN & OTTONE, NICOLÁS. Evaluación histológica de los daños ocasionados por MIA en articulación humeral de rata. Proyecto DIUFRO FONDOS PROPIOS DFP16-0012, Universidad de La Frontera. Temuco, Chile. 2017 al 2018. Cargo desempeñado: Co-investigador.


ALARCÓN, VALENTINA. Actividad de colaboración entre Citizen Schools y Nexos Chile-USA. Esta colaboración permitió la visita de un Colegio de Valdivia a Boston, en donde los miembros pertenecientes a dicho núcleo los recibieron en las instalaciones de Citizen Schools. Durante este encuentro, chilenos residentes en el extranjero contaron su experiencia a los niños. 2016.

MUÑOZ-RAMIREZ, CARLOS. Proyecto NSF-DDIG para estudiar las consecuencias del Mimetismo Mulleriano en la generación de diversidad. Proyecto NSF. University of Michigan, Ann Arbor. Ann Arbor, Michigan, USA. 2016.

SANDOVAL, CRISTIAN; OLAVE, ENRIQUE & VÁSQUEZ, BÉLGICA. Efectos de la dieta alta en grasa sobre las características morfológicas de la glándula suprarrenal de ratón C57BL/6. Proyecto DIUFRO DI16-0111, Universidad de La Frontera. Temuco, Chile. 2016 al 2017. Cargo desempeñado: Investigador Responsable.

DEL SOL, MARIANO; SANDOVAL, CRISTIAN & VÁSQUEZ, BÉLGICA. Efectos de la administración oral de betacaroteno sobre la sensibilidad a insulina y características morfocuantitativas del hígado y páncreas en ratones C57BL/6 expuestos previamente al consumo de etanol en dosis baja y moderada. Proyecto DIUFRO DI16-0132, Universidad de La Frontera. Temuco, Chile. 2016 al 2017. Cargo desempeñado: Co-investigador.


TANG, YU-WEN & FLORES, PATRICIO. Sales strategy development for a highly stable glutamate dehydrogenase, GDH. Go to Market 13GTM-21978, Corporación de Fomento de la Producción. Santiago, Chile. 2013. Cargo desempeñado: Investigador Responsable.

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